What question did this study set out to answer?

The research aims to understand how specific sites in CYP512W2 influence its catalytic behavior and the resulting product outcomes.

April 10, 2026

Multifunctional switch mediates the catalytic activity and product ratio in fungal CYP512W2

Key Points

The research aims to understand how specific sites in CYP512W2 influence its catalytic behavior and the resulting product outcomes.
Characterization of the CYP512W2 enzyme
Site-directed mutagenesis of amino acids I108 and I364
Analysis of changes in catalytic activity and product ratios
Mutations I108N and I364H reversed the product selectivity
Mutations I108S and I364C increased total production of products

Abstract

Critical sites I108 and I364 in fungal CYP512W2 act as “multifunctional switches” governing catalytic activity and product ratio. I108N and I364H reverses product selectivity, while I108S and I364C enhance the total production.

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Cite this study

Li et al. (Thu,) studied this question.

synapsesocial.com/papers/69d894526c1944d70ce05405 — DOI: https://doi.org/10.1039/d6cy00114a

Authors

Hanbing Li

Shanghai Jiao Tong University

Yan Luo

Southwest University

Zeqian Du

Shanghai Jiao Tong University

Journals

Catalysis Science & Technology

Actions

Institutions

Shanghai Jiao Tong University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Multifunctional switch mediates the catalytic activity and product ratio in fungal CYP512W2

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion