Chronic Glycaemic Control Modulates the Relationship Between GIP and Glucagon Secretion Following Oral and Enteral Nutrients in Type 2 Diabetes

Key Points

• The study aims to explore how chronic glycaemic control influences the relationship between GIP and glucagon secretion after nutrient intake in type 2 diabetes.
• Conducted a multivariable analysis of glucagon levels following oral and enteral nutrient administration.
• Measured glycaemic control through standardized metrics in participants with type 2 diabetes.
• Evaluated the interrelationship between GIP levels and glucagon secretion post-nutrient exposure.
• Chronic glycaemic control significantly altered the relationship between GIP and glucagon secretion.
• Glucagon levels were higher in participants with poor glycaemic control after nutrient intake.
• GIP showed varying effects on glucagon secretion based on glycaemic control status.