Quantifying brain-age gap in people with HIV on antiretroviral therapy using plasma neurofilament light chain

Key Points

• The research aims to quantify the brain-age gap in individuals living with HIV on antiretroviral therapy and its implications for cognitive health.
• Analyzed plasma neurofilament light chain (NfL) levels
• Identified participants who are cognitively unimpaired on ART
• Assessed cognitive outcomes and aging biomarkers
• A substantial brain-age gap was observed in cognitively unimpaired individuals with HIV
• The gap increased in participants who experienced subsequent cognitive decline