What question did this study set out to answer?

This research aims to explore the link between genetic polymorphisms in oxidative stress-related genes and radiotherapy toxicity in head and neck cancer patients.

April 10, 2026Open Access

Genetic Polymorphisms in Genes Involved in Oxidative Stress and Their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients

Key Points

This research aims to explore the link between genetic polymorphisms in oxidative stress-related genes and radiotherapy toxicity in head and neck cancer patients.
Analyzed genetic polymorphisms in extracellular superoxide dismutase (SOD3)
Assessed radiation-induced skin toxicity
Evaluated mucositis severity among head and neck cancer patients
Identified significant association of SOD3 polymorphisms with radiation-induced skin toxicity
Found correlation between SOD3 variants and mucositis severity among patients

Abstract

The analysis of genetic polymorphisms in extracellular superoxide dismutase (SOD3) revealed a statistically significant association with radiation-induced skin toxicity and mucositis among HNC patients in the studied population.

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