What question did this study set out to answer?

To evaluate the effectiveness of high-dose-rate interstitial brachytherapy in treating cutaneous squamous cell carcinoma in patients with xeroderma pigmentosum.

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April 10, 2026Open Access

Successful Interstitial HDR Brachytherapy for Nasal Skin SCC in Xeroderma Pigmentosum: An Eight‐Year Follow‐Up Case Report

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Key Points

To evaluate the effectiveness of high-dose-rate interstitial brachytherapy in treating cutaneous squamous cell carcinoma in patients with xeroderma pigmentosum.
Long-term follow-up of a patient with xeroderma pigmentosum and cutaneous squamous cell carcinoma
Treatment with high-dose-rate interstitial brachytherapy
Assessment of local control and cosmetic outcomes
Durable local control of squamous cell carcinoma was achieved
Acceptable cosmetic outcomes noted after treatment
Challenges the notion that radiotherapy is an absolute contraindication in xeroderma pigmentosum

Abstract

ABSTRACT High‐dose‐rate interstitial brachytherapy may provide durable local control with acceptable cosmetic outcomes in carefully selected patients with xeroderma pigmentosum and cutaneous squamous cell carcinoma. This long‐term follow‐up case questions the absolute contraindication of radiotherapy in XP and underscores the importance of individualized treatment planning based on underlying DNA repair mechanisms.

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Authors

Pouya Saraei

Ahvaz Jundishapur University of Medical Sciences

Vita Derakhshandeh

Iran University of Medical Sciences

Ali Bagheri

Journals

Clinical Case Reports

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Institutions

Iran University of Medical Sciences

Ahvaz Jundishapur University of Medical Sciences

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Cite this study

Saraei et al. (Wed,) studied this question.

synapsesocial.com/papers/69d895ea6c1944d70ce07110 — DOI: https://doi.org/10.1002/ccr3.72516

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Xeroderma Pigmentosum and Skin Cancer· 2008 · 33 citations
Radiothérapie des cancers cutanés au cours du xeroderma pigmentosum· 2011 · 7 citations
Radiation Therapy for High-Risk Squamous Cell Carcinomas in Patients with Xeroderma Pigmentosum: Report of Two Cases and Review of the Literature· 2011 · 24 citations
Comprehensive Brachytherapy: Physical and Clinical Aspects.· 2013 · 52 citations
Shining a Light on Xeroderma Pigmentosum· 2012 · 533 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Xeroderma Pigmentosum and Skin Cancer· 2008 · 33 citations
Radiothérapie des cancers cutanés au cours du xeroderma pigmentosum· 2011 · 7 citations
Radiation Therapy for High-Risk Squamous Cell Carcinomas in Patients with Xeroderma Pigmentosum: Report of Two Cases and Review of the Literature· 2011 · 24 citations
Comprehensive Brachytherapy: Physical and Clinical Aspects.· 2013 · 52 citations
Shining a Light on Xeroderma Pigmentosum· 2012 · 533 citations

Successful Interstitial HDR Brachytherapy for Nasal Skin SCC in Xeroderma Pigmentosum: An Eight‐Year Follow‐Up Case Report

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider