Regulation of IRGM1-Mediated Pyroptosis and Neuroinflammation by Transcription Factor NR3C1 Alleviates Early Brain Injury After Subarachnoid Hemorrhage

Key Result

NR3C1 activation of IRGM1 alleviates early brain injury after subarachnoid hemorrhage by inhibiting inflammation, pyroptosis, and oxidative stress.

Key Points

• This research aims to explore how NR3C1 influences IRGM1 in regulating inflammation and pyroptosis after subarachnoid hemorrhage.
• Activated NR3C1 to study its transcriptional effects on IRGM1.
• Assessed levels of inflammation and oxidative stress in brain tissues post-SAH.
• Evaluated neuronal damage to measure early brain injury outcomes.
• NR3C1 activation significantly reduced neuroinflammation and pyroptosis.
• Oxidative stress levels were markedly lower in the presence of active NR3C1.
• Early brain injury outcomes improved following modulation of the NR3C1/IRGM1 axis.