September 16, 2011Open Access

Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

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Abstract

Hypoxic regions are present in murine plaques. Hypoxic macrophages have increased sterol content due to the induction of sterol synthesis and the suppression of cholesterol efflux, effects that are in part mediated by HIF-1α.

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Parathath et al. (Fri,) studied this question.

synapsesocial.com/papers/69d8a7f952654bb436d19a80 https://doi.org/https://doi.org/10.1161/circresaha.111.246363

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