Identifies BAG3 variants as genetic contributors to both monogenic and sporadic forms of dilated cardiomyopathy.
This GWAS identified two loci involved in sporadic DCM, one of them probably implicates BAG3. Our results show that rare mutations in BAG3 contribute to monogenic forms of the disease, while common variant(s) in the same gene are implicated in sporadic DCM.
Villard et al. (Fri,) studied this question.
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