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February 20, 2018European Heart JournalOpen Access

The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent

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Why the study?

Does increasing adiposity affect the incidence of cardiovascular disease, and is the obesity paradox explained by confounding in BMI measurements?

Population

296,535 middle-aged men and women of white European descent

Design

Cohort

Authors

SIStamatina IliodromitiCCCarlos Celis‐MoralesDLDonald M. Lyall

Discussion

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Member takes

Overview

Questions BMI-based obesity paradox interpretations in practice; supports confounding explanation but leaves causal effects of adiposity open.

Structured PICO

Does increasing adiposity affect the incidence of cardiovascular disease, and is the obesity paradox explained by confounding in BMI measurements?

P
Population
296,535 middle-aged men and women of white European descent
I
Intervention
Increasing adiposity (evaluated via BMI and other adiposity measures)
O
Outcome
Incidence of cardiovascular diseasehard clinical

The obesity paradox is an artifact of confounding related to BMI and pre-existing comorbidities, confirming that increasing adiposity is detrimental to cardiovascular health.

Cite This Study

Iliodromiti et al. (2018) studied this question.

synapsesocial.com/papers/69d966669a6164e50fa3cc1bhttps://doi.org/10.1093/eurheartj/ehy057
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