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December 1, 1971Chemical Reviews4,549 citations

Partition coefficients and their uses

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ALAlbert J. LeoCHCorwin HanschDEDavid Elkins

Key Points

  • This review aims to detail the significance and applications of partition coefficients in chemistry.
  • Comprehensive analysis of existing literature on partition coefficients.
  • Discussion of molecular interactions affected by partition coefficients.
  • Evaluation of different methodologies for measuring partition coefficients.
  • Partition coefficients serve as essential indicators of solubility and lipophilicity in compounds.
  • They provide insights into drug formulation and environmental chemistry.
  • Applications in predicting biological behavior of molecules were emphasized.

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPartition coefficients and their usesAlbert Leo, Corwin Hansch, and David ElkinsCite this: Chem. Rev. 1971, 71, 6, 525–616Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/cr60274a001https://doi.org/10.1021/cr60274a001research-articleACS PublicationsRequest reuse permissionsArticle Views17110Altmetric-Citations3802LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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Leo et al. (1971) studied this question.

synapsesocial.com/papers/69d9774a0d540cafc583584chttps://doi.org/10.1021/cr60274a001
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