Rhesus blood group haplotype determination by nanopore sequencing and adaptive sampling enables the precise determination of complex allele combinations that could not be accurately determined by standard methods

Key Points

• This research aims to enhance the precision of genotyping for the Rhesus blood group using advanced sequencing techniques.
• Utilized nanopore sequencing with adaptive sampling technology
• Focused on genotyping the RH blood group system
• Analyzed complex allele combinations present in subjects
• Achieved unambiguous genotyping of the RH system
• Improved detection of complex variants within the Rhesus blood group
• Facilitated better transfusion strategies for patients requiring chronic transfusions