Novel genetic loci at GJA1 and CD46/MIR29B2CHG were identified in a Taiwanese cohort as influencing QT interval and potential susceptibility to sudden cardiac death.
Identified novel genetic loci (GJA1 and CD46/MIR29B2CHG) associated with QT interval in a Taiwanese population, highlighting potential population-specific mechanisms for ventricular repolarization and sudden cardiac death risk.
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This is the first GWAS of QT interval in a Taiwanese cohort, revealing novel loci at GJA1 and CD46/MIR29B2CHG. These genes may influence ventricular repolarization and susceptibility to SCD through electrotonic load (GJA1), inflammation (CD46) or microRNA (MIR29B2CH).
Huang et al. (Fri,) reported a other. Novel genetic loci at GJA1 and CD46/MIR29B2CHG were identified in a Taiwanese cohort as influencing QT interval and potential susceptibility to sudden cardiac death.