February 5, 2019

Activated and Exhausted MAIT Cells Foster Disease Progression and Indicate Poor Outcome in Hepatocellular Carcinoma

Key Points

Key points are not available for this paper at this time.

Abstract

HCC-infiltrating MAIT cells were functionally impaired and even reprogrammed to shift away from antitumor immunity and toward a tumor-promoting direction.See related commentary by Carbone, p. 3199.

AI से पूछें

Bookmark

Cite This Study

Duan et al. (Tue,) studied this question.

synapsesocial.com/papers/69dab528a6045d71bfa3de71 https://doi.org/https://doi.org/10.1158/1078-0432.ccr-18-3040

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?2013 · 1,073 citations
2NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma2011 · 1,348 citations
3Analysis of CD161 expression on human CD8 <sup>+</sup> T cells defines a distinct functional subset with tissue-homing properties2010 · 368 citations
4NFKB1 regulates human NK cell maturation and effector functions2016 · 45 citations
5Immune surveillance by the liver2013 · 1,018 citations

AI से पूछें

Bookmark