BackgroundNon-invasive neuromodulation technologies have advanced considerably.Yet, precise and focal activation of deep brain regions remains challenging due to the rapid attenuation of electric fields across the scalp, skull and brain surface. ObjectiveWe present FLOATES (FLOAting Transcranial Electrical Stimulation), a novel approach that employs an untethered wire implanted in the brain which passively relays currents injected transcranially from the brain surface to deep brain regions, achieving focused stimulation deep within the brain. MethodsWe validated FLOATES through a combination of simulations, benchtop testing, and in vivo rodent studies.The benchtop experiments confirmed the ability to relay the field across the floating wire.Rodent studies demonstrated capability to stimulate deep brain regions in vivo. ResultsOur simulation and benchtop testing results indicate that FLOATES can deliver significantly higher electric fields to subcortical regions compared to conventional transcranial stimulation approaches.Further in-vivo results demonstrated deep subthalamic nuclei stimulation to evoke limb motor responses and demonstrated a significantly lower motor threshold compared to transcranial stimulation.Finite element simulations reveal that the efficiency of FLOATES depends on several key parameters including input field strength, wire length and diameter, exposed electrode area, electrode impedance, and tip geometry.Simulations using a humansized head model suggest that electric fields sufficient for brain stimulation can be obtained with reasonable currents injected to the scalp. ConclusionTogether, these results establish a theoretical and experimental foundation for FLOATES as a minimally invasive and spatially precise brain stimulation platform in modulating deep neural circuits implicated in neuropsychiatric and movement disorders.
Jain et al. (Wed,) studied this question.