Enhancement of tobramycin and amikacin activities by co-encapsulation in liposomal-thymoquinone formulation: antibacterial, antibiofilm, and cytocompatibility study

Key Points

• To evaluate the effects of co-encapsulation of tobramycin and amikacin with thymoquinone in liposomes on antibacterial activity, antibiofilm properties, and cytocompatibility.
• Co-encapsulation of antibiotics in liposomal formulations with thymoquinone.
• Assessment of antibacterial and antibiofilm activities.
• Evaluation of cytocompatibility.
• Improved antibacterial effectiveness was observed with the co-encapsulated formulation.
• Enhanced ability to combat biofilm formation was noted.
• Cytocompatibility was maintained despite the formulation.