What question did this study set out to answer?

This research aims to explore the MYC–ribosome axis and its role in aging and tumor biology.

April 12, 2026Open Access

Multi-layered erosion of the MYC–ribosome axis defines a universal aging programme co-opted by tumour cells

Key Points

This research aims to explore the MYC–ribosome axis and its role in aging and tumor biology.
Processed single-cell RNA sequencing (scRNA-seq) data analyzed across breast, colon, and lung tissues.
Datasets include both normal and tumor conditions for comparison.
Cell metadata and preprocessing steps documented in README.txt.
Datasets reveal a universal aging programme influenced by the MYC–ribosome axis in tumor cells.
Age-balanced subsets demonstrate model-predicted biological age across tissues.

Abstract

This is the collection of datasets described in the paper "Multi-layered erosion of the MYC–ribosome axis defines a universal aging programme co-opted by tumour cells" This repository contains: Processed scRNA-seq matrices in h5ad format across three tissues (breast, colon, lung) under normal and tumor conditions README. txt providing information on the analyzed datasets, cell metadata, and data preprocessing steps The descriptions for each item are as follows: Full processed post-QC log-normalized scRNA-seq matrix files by tissue and condition: 'scRNAdataset. tar' ('breastₙormalₐdata. h5ad', 'breastₜumorₐdata. h5ad', 'colonₙormalₐdata. h5ad', 'colonₜumorₐdata. h5ad', 'lungₙormalₐdata. h5ad', 'lungₜumorₐdata. h5ad') Age-balanced subset selected via geometric sketching, with model-predicted biological age (Predₐge): 'scRNAgsket. tar' Raw count matrices can be downloaded from the accession links in README. txt Analysis codes are available at: https: //github. com/nccpai/PriorAge

Multi-layered erosion of the MYC–ribosome axis defines a universal aging programme co-opted by tumour cells

Key Points

Abstract

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