What question did this study set out to answer?

To evaluate the effectiveness of low-dose esketamine added to dexmedetomidine for sedation and analgesia during local anesthesia procedures.

April 12, 2026

Effectiveness of adding esketamine to dexmedetomidine for sedation and analgesia during radiofrequency ablation and saphenous vein stripping: a randomized controlled trial

Key Points

To evaluate the effectiveness of low-dose esketamine added to dexmedetomidine for sedation and analgesia during local anesthesia procedures.
Randomized controlled trial design
Comparison between two groups: esketamine and dexmedetomidine (group DE) vs. dexmedetomidine and fentanyl (group DF)
Assessment of analgesia and sedation quality during radiofrequency ablation of the great saphenous vein
Group DE provided better cardiovascular stability compared to group DF
Both groups effectively achieved sedation and analgesia
Combination of esketamine and dexmedetomidine is a promising regimen for local anesthesia surgeries

Abstract

Both experimental groups (DF and DE) provide effective analgesia and sedation during RA of the great saphenous vein under local anesthesia. However, in our study, low-dose esketamine combined with dexmedetomidine (group DE) is superior due to better cardiovascular stability that is achieved compared to dexmedetomidine and fentanyl (group DF). This combination may serve as a promising adjuvant analgesic and sedative regimen for surgeries conducted under local anesthesia.

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Cite This Study

LI et al. (Wed,) studied this question.

synapsesocial.com/papers/69db38534fe01fead37c6892 https://doi.org/https://doi.org/10.23736/s0375-9393.26.19169-x

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