The vasculature is more susceptible to the deleterious effects of nutrient overload than other tissues, developing inflammation and insulin resistance earlier.
During obesity induced by HF feeding, inflammation and insulin resistance develop in the vasculature well before these responses are detected in muscle, liver, or adipose tissue. This observation suggests that the vasculature is more susceptible than other tissues to the deleterious effects of nutrient overload.
Kim et al. (Fri,) studied this question.