May 15, 2025

ECM1 protects against liver steatosis through PCBP1-mediated iron homeostasis

Key Points

Key points are not available for this paper at this time.

Abstract

Our study reveals that ECM1 is a critical regulator in MASH, modulating lipid peroxidation by maintaining PCBP1-mediated intracellular iron homeostasis. Targeting ECM1 to restore PCBP1-dependent iron homeostasis may offer a novel therapeutic avenue for MASH.

Bookmark

Cite This Study

Zhang et al. (Thu,) studied this question.

synapsesocial.com/papers/69dcc45ea5c75be4cfe5402c https://doi.org/https://doi.org/10.1097/hep.0000000000001402

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1ECM1 controls TH2 cell egress from lymph nodes through re-expression of S1P12011 · 63 citations
2Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial2019 · 765 citations
3The Human Extracellular Matrix Gene 1 (ECM1): Genomic Structure, cDNA Cloning, Expression Pattern, and Chromosomal Localization1997 · 102 citations
4Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP12021 · 43 citations
5Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis2020 · 174 citations