Are multiple oral doses of apixaban safe and what are their pharmacokinetic and pharmacodynamic profiles in healthy subjects?
Multiple oral doses of apixaban demonstrated a favorable safety profile, predictable pharmacokinetics, and dose-dependent pharmacodynamics in healthy subjects.
Multiple oral doses of apixaban were safe and well tolerated over a 10-fold dose range, with pharmacokinetics with low variability and concentration-related increases in clotting time measures.
Frost et al. (Tue,) studied this question.