Does acute GLP-1R agonism induce arrhythmogenic electrical activity in aged mice?
Acute GLP-1 receptor agonism induces arrhythmogenic electrical activity in aged mice via CK2 hyperphosphorylation, suggesting a potential pro-arrhythmic mechanism to consider in the elderly.
These findings reveal that acute GLP-1R agonism can disrupt electrical signaling and induce arrhythmia in aged mice through CK2 hyperphosphorylation, providing new insights into the cardiovascular effects of GLP-1RAs in the elderly.
Yusuf Olğar (Tue,) studied this question.