February 18, 2010Open Access

Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart

Structured PICO

Population

Failing heart model (specifics not provided in abstract)

Identified a novel cellular pathway of gap junction internalization and degradation in the failing heart, offering potential therapeutic targets.

Abstract

Our data demonstrate a previously unrecognized pathway of gap junction internalization and degradation in the heart and identify a cellular pathway with potential therapeutic implications.

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Cite This Study

Hesketh et al. (Thu,) studied this question.

synapsesocial.com/papers/69dd3e907808b00a4799baa5 https://doi.org/https://doi.org/10.1161/circresaha.108.182147

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1Autophagy: from phenomenology to molecular understanding in less than a decade2007 · 1,929 citations
2The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein1998 · 525 citations
3Five-hour half-life of mouse liver gap-junction protein.1981 · 327 citations
4Modulation of cell junctions during differentiation of the chicken otocyst sensory epithelium1979 · 165 citations
5So-called annular gap junctions in bone cells of normal mice1977 · 20 citations

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