Can in vivo DT-MRI map fiber architecture remodeling and correlate with infarct size and LV function in human myocardium after infarction?
In vivo DT-MRI can effectively map fiber architecture remodeling in postinfarct human myocardium, providing structural correlates for functional remodeling.
In vivo DT-MRI of postinfarct myocardium revealed a significant increase in trace ADC and a decrease in FA, indicating altered tissue integrity. The redistribution of fiber architecture correlated with infarct size and left ventricular function. This technique may help us understand structural correlates of functional remodeling after infarction.
Wu et al. (2006) studied this question.