Clinical significance and regulatory mechanism of miR-4284 in lumbar intervertebral disc degeneration

Key Points

• The aim is to evaluate the role of miR-4284 as a biomarker in lumbar intervertebral disc degeneration (LDD) and its underlying mechanisms.
• Analyzed miR-4284 levels in lumbar intervertebral disc tissues.
• Examined its effects on inflammation and mitochondrial function in nucleus pulposus (NP) cells.
• Investigated the relationship between miR-4284 and CYCS.
• miR-4284 levels were significantly lower in cases of LDD.
• Targeting CYCS by miR-4284 reduced inflammation and oxidative stress in NP cells.
• miR-4284 inhibited apoptosis and improved mitochondrial function, which may slow LDD progression.