Abstract: Psoriasis is a chronic, immune-mediated skin disorder characterized by hyperprolifera-tion of keratinocytes and persistent inflammation driven by dysregulated cytokine signaling. Conventional therapies, though effective, are often limited by systemic toxicity, inadequate skin penetration, and poor patient compliance. In recent years, nanotechnology-based herbal delivery systems have emerged as promising alternatives to overcome these limitations. This review high-lights the rationale, formulation strategies, and therapeutic mechanisms underlying synergistic herbal nanoemulgels containing curcumin and cinnamon oil for psoriasis management. The com-bined phytoconstituents exhibit complementary anti-inflammatory, antioxidant, antimicrobial, and skin-healing properties, primarily through inhibition of NF-κB, COX-2, and MAPK signal-ing, alongside modulation of oxidative stress pathways. Integration into nanoemulsion-based gel matrices enhances solubility, stability, and dermal permeation of these bioactives, ensuring local-ized, sustained release with minimal irritation. The article further discusses formulation compo-nents, characterization techniques, and findings from in vitro and in vivo models demonstrating significant reductions in erythema, scaling, and cytokine expression. Safety assessments reveal excellent dermal compatibility, while translational prospects suggest scalability and regulatory feasibility for clinical applications. Collectively, curcumin and cinnamon nanoemulgels represent a novel, patient-friendly, and mechanistically rational platform for targeted topical therapy in psoriasis and related inflammatory dermatoses.
Pundir et al. (Wed,) studied this question.