Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.2000 · 543 citations
2. 2Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.1997 · 215 citations
3. 3DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal1990 · 213 citations
4. 4Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.1996 · 246 citations
5. 5Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain.1993 · 102 citations