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March 1, 1994Circulation516 citations

Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.

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BSBojung SeoBOBarry S. OemarRSR Siebenmann

Key Points

  • Investigate the role of ETA and ETB receptors in the contraction of human blood vessels to endothelin-1.
  • Analyzed vascular smooth muscle cells from human IMA, IMV, and PCA for receptor expression.
  • Assessed the presence of functional ETB receptors linked to nitric oxide and prostacyclin.
  • Evaluated the need for combined ETA/ETB antagonists to inhibit endothelin-induced contraction.
  • Both ETA and ETB receptors are present in vascular smooth muscle cells of human blood vessels.
  • Endothelium of IMA and PCA lacks functional ETB receptors associated with nitric oxide and prostacyclin production.
  • Contraction inhibition in response to endothelin requires combined antagonism of both receptors.

Abstract

Vascular smooth muscle cells of human IMA, IMV, and PCA contain both ETA and ETB receptors, whereas the endothelium of IMA and PCA does not express functional ETB receptors linked to nitric oxide and/or prostacyclin production. Hence, inhibition of endothelin-induced contraction in patients requires the use of combined ETA/ETB antagonists.

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Cite This Study

Seo et al. (1994) studied this question.

synapsesocial.com/papers/69def5c5499d77a496b0d3ddhttps://doi.org/10.1161/01.cir.89.3.1203
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