Topoisomerase 1-DNA complexes are preferentially recognised by a subset of anti-topoisomerase 1 autoantibodies and their corresponding B cell receptors in systemic sclerosis | Synapse
April 15, 2026Open Access
Topoisomerase 1-DNA complexes are preferentially recognised by a subset of anti-topoisomerase 1 autoantibodies and their corresponding B cell receptors in systemic sclerosis
Key Points
This research examines how certain autoantibodies recognize topoisomerase 1 when it binds to DNA, exploring variations in the immune response among individuals with systemic sclerosis.
Analyzed autoantibody responses to topoisomerase 1 in systemic sclerosis samples.
Investigated B cell receptor interactions with topoisomerase 1-DNA complexes.
Assessed the heterogeneity of the antibody response in relation to disease severity.
Identified a specific subset of autoantibodies that preferentially recognize topoisomerase 1-DNA complexes.
Highlighted a diverse B cell response linked to the presence of topoisomerase 1 in systemic sclerosis patients.
Suggested that this variation may influence the progression and severity of the disease.
Abstract
The differential recognition of TOP1 upon DNA binding by ATAs demonstrates heterogeneity in the ATA B cell response, possibly impacting disease-relevant processes in severe SSc.
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Cite This Study
Neppelenbroek et al. (Wed,) studied this question.