What question did this study set out to answer?

The research aims to explore the role of EDIL3 in regulating vascular permeability and angiogenesis in subchondral bone during osteoarthritis.

April 15, 2026Open Access

EDIL3 regulates caveolin-1-dependent endothelial permeability in subchondral bone during osteoarthritis

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Key Points

The research aims to explore the role of EDIL3 in regulating vascular permeability and angiogenesis in subchondral bone during osteoarthritis.
Analyzed endothelial permeability in subchondral bone
Examined the effects of EDIL3 on vascular function
Investigated the relationship between EDIL3 and caveolin-1
EDIL3 is crucial in mediating endothelial permeability
Increased angiogenesis was linked to EDIL3 activity
Targeting EDIL3 may help restore bone homeostasis in osteoarthritis

Abstract

These findings suggest that EDIL3 functions as an important mediator of pathological vascular permeability and angiogenesis in the subchondral bone during OA progression. Targeting EDIL3 to restore subchondral bone microenvironment homeostasis may represent a novel therapeutic strategy for OA management.

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Cite this study

Ma et al. (Mon,) studied this question.

synapsesocial.com/papers/69df2b85e4eeef8a2a6b089f — DOI: https://doi.org/10.1016/j.intimp.2026.116637

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Authors

Ye Ma

Xinjiang Institute of Materia Medica

Ke Feng

Qingdao University of Science and Technology

Kuanmin Tian

Ningxia Medical University

Journals

International Immunopharmacology

Actions

Institutions

Ningxia Medical University

Ningxia Medical University General Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

EDIL3 regulates caveolin-1-dependent endothelial permeability in subchondral bone during osteoarthritis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider