Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer

Key Points

• To investigate how polygenic risk scores (PRS) affect colorectal cancer (CRC) risk in different onset groups and genetic backgrounds.
• Analyzed the influence of PRS on CRC risk across late-onset and early-onset types.
• Examined familial and hereditary cases of CRC.
• Considered sample sizes and study design to explain variations in findings.
• PRS significantly impacts CRC risk in unexplained early-onset and familial cases.
• Effectiveness in Lynch syndrome individuals varies with gene penetrance and study design.
• Non-significant trends observed suggest influence from subgroup sample sizes.