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April 16, 2026

Somatic copy number variations as long-term genomic biomarkers of ionizing radiation exposure in individuals accidentally exposed to Cesium-137 during the Goiânia radiological accident

Key Points

The study aims to investigate somatic copy number variations as long-term genomic biomarkers of radiation exposure.
Analyzed somatic CNVs in individuals exposed to Cesium-137 during the Goiânia accident.
Utilized CNV profiling techniques to assess genomic signatures.
Evaluated the persistence of CNVs decades after exposure.
Somatic CNVs remained quantifiable biomarkers of ionizing radiation exposure long after the event.
CNV profiling was identified as a potential tool for retrospective biodosimetry.
Findings support CNV use in long-term health monitoring and radiological risk assessment frameworks.

Abstract

The findings demonstrated that somatic CNVs persist as quantifiable genomic signatures of ionizing radiation exposure even decades after the event. CNV profiling represents a promising tool for retrospective biodosimetry and long-term health surveillance of exposed populations, reinforcing its potential role in radiological protection and genomic risk assessment frameworks.

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