What question did this study set out to answer?

This research aims to investigate how Ca2+ influences the effectiveness of prodelphinidin B digallate in reducing postprandial hyperglycemia.

April 17, 2026Open Access

Ca2+ enhances the activity of prodelphinidin B digallate in lowering postprandial hyperglycemia via regulating the mucus layer

Key Points

This research aims to investigate how Ca2+ influences the effectiveness of prodelphinidin B digallate in reducing postprandial hyperglycemia.
Examined the interaction of Ca2+ with the mucus layer
Analyzed the effects on prodelphinidin B digallate absorption
Investigated the inhibition of α-glucosidase activity
Ca2+ improved the mucus barrier properties, enhancing prodelphinidin B digallate delivery
Prodelphinidin B digallate showed increased inhibition of α-glucosidase
Consequently, there was a reduction in postprandial hyperglycemia

Abstract

Ca2+ regulates the barrier properties of the mucus layer, thereby promoting proDB DG to reach the mucosa quickly and then interact with α-glucosidase effectively, which may break the application limitations of proDB DG and even phenolic compounds as α-glucosidase inhibitors clinically.

Read Full Paperexternally

Bookmark

View Full Paper

Cite This Study

Wáng et al. (Wed,) studied this question.

synapsesocial.com/papers/69e1cd6f5cdc762e9d856ed2 https://doi.org/https://doi.org/10.1016/j.jare.2026.04.031

Bookmark

View Full Paper