Safety of Pre‐Operative Radiotherapy Combined With Intraoperative Radiotherapy for Retroperitoneal Sarcoma

Key Points

• To evaluate the safety and complication rates of combining neoadjuvant external beam radiotherapy (EBRT) with intraoperative radiotherapy (IORT) for patients with retroperitoneal sarcoma.
• Conducted a clinical assessment of patients receiving neoadjuvant EBRT followed by IORT.
• Analyzed complication rates post-surgery comparing combined therapy versus EBRT alone.
• Monitored both low-grade and major complications.
• Identified a frequent occurrence of low-grade complications.
• Reported a 25% rate of major complications in the combined therapy group.
• Findings indicate complication rates are similar to those observed with neoadjuvant EBRT alone.