AbstractPurpose To compare MRI-based prostate volume measurements by radiologists using the ellipsoid formula with two CE-marked AI models in a population-based screening cohort of 50-year-old men, and to evaluate the impact on PSAD-based biopsy recommendations. Methods This retrospective method-agreement study included 303 prostate MRI examinations from Swedish organised prostate cancer testing programmes between 2020 and 2022. Examinations were performed at 14 radiology departments using scanners from multiple vendors and field strengths. Prostate volumes were measured by local radiologists using the PI-RADS–recommended ellipsoid formula and by two CE-marked AI models based on automated whole-gland segmentation. Agreement for prostate volume and PSAD was assessed using Bland–Altman analysis. Biopsy recommendations were evaluated in men with PI-RADS 1–3 lesions using clinically relevant PSAD thresholds. Results The mean volume differences between radiologists and AI models were Conclusions In a screening population of 50-year-old men, CE-marked AI models demonstrated good agreement with radiologists for MRI-based prostate volume estimation, with comparable PSAD-based biopsy recommendations. AI-based volume assessment may reduce variability and radiologist workload in prostate cancer screening.
Thimansson et al. (Wed,) studied this question.