Spatiotemporal dynamics of seizure networks: Progressive posterior hippocampal recruitment in mesial temporal lobe epilepsy

Key Points

• This research investigates how the duration of mesial temporal lobe epilepsy affects seizure networks, particularly in the hippocampus.
• Analyzed the relationship between disease duration and structural changes.
• Identified patterns of recruitment in the posterior hippocampus.
• Evaluated the implications for surgical resection strategies.
• Longer disease duration correlates with increased structural atrophy after 15 years.
• The posterior hippocampus shows greater epileptogenicity with extended disease duration.
• Findings support personalized approaches to surgical intervention in chronic cases.