What question did this study set out to answer?

To isolate and characterize a new stilbene with anticancer activity from Macaranga aenigmatica.

April 19, 2026Natural Product Research0 citations

An undescribed stilbene from macaranga aenigmatica whitmore and its anticancer activity

TTTjitjik Srie TjahjandarieAirlangga University WSWidya Eko SusilowatiAirlangga University AUAji Setyo UtomoAirlangga University

Key Points

To isolate and characterize a new stilbene with anticancer activity from Macaranga aenigmatica.
Isolation of compounds from Macaranga aenigmatica leaves
Structural determination using ESI-HRMS and NMR
Cytotoxicity testing on HeLa and P-388 cell lines
Macaenigmaticin A showed potent activity against P-388 cells with an IC50 of 1.15 µg/mL
Macapruinosin A also exhibited activity against P-388 cells with an IC50 of 1.53 µg/mL
Stilbenes were inactive against HeLa cells.

Abstract

An undescribed stilbene, macaenigmaticin A (1), together with two known compounds, mappain (2) and macapruinosin A (3), were isolated from Macaranga aenigmatica Whitmore leaves. The structure of 1 was determined from a combination of ESI-HRMS and NMR spectra. Cytotoxicity was tested against the HeLa (cervical cancer) and P-388 (murine leukaemia) cell lines. Macaenigmaticin A (1) and macapruinosin A (3) were potent against P-388 cells, with IC50 values of 1.15 and 1.53 µg/mL, respectively. Stibenes 1-3 were inactive against HeLa cells.

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