What question did this study set out to answer?

This research aims to evaluate how drug-related cues influence craving during withdrawal in individuals with methamphetamine use disorder.

April 19, 2026Open Access

The Phase‐Amplitude Coupling Induced by Drug Cues in Individuals With Methamphetamine Use Disorder During Withdrawal

Key Points

This research aims to evaluate how drug-related cues influence craving during withdrawal in individuals with methamphetamine use disorder.
Analyzed the effects of drug cues on craving intensity.
Investigated phase-amplitude coupling (PAC) and other neural interactions.
Assessed participants during withdrawal to measure neural responses.
Utilized predictive biomarkers for craving severity evaluation.
Drug cues significantly increased craving levels.
PAC and other biomarkers correlated with craving severity.
Findings highlight the role of prefrontal regulation in craving responses.

Abstract

Drug-related cues may exacerbate craving by weakening top-down prefrontal regulation and amplifying bottom-up sensorimotor drive. PAC and PSI represent promising cue-reactive predictive biomarkers for evaluating the neural substrates of drug cue-induced craving severity in individuals with MUD.

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