Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu | Synapse
April 19, 2026Open Access
Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu
Key Points
This research aims to determine how leptin affects eosinophil behavior and angiogenesis in chronic rhinosinusitis with nasal polyps (CRSwNP) under Type 2 inflammation.
Examined the role of leptin in eosinophil migration and angiogenesis.
Analyzed the involvement of chemokine ligands and PAI-1.
Investigated the effects in a Type 2 inflammatory context.
Increased angiogenesis was noted in the presence of leptin.
The findings suggest a potential role of leptin in worsening CRSwNP.
Abstract
Leptin promotes eosinophil migration and angiogenesis, potentially via chemokine ligands and PAI-1 induction, and may promote CRSwNP progression under a Type 2 inflammatory milieu.