Advances in bioelectrocatalysis are reshaping exercise physiology by enabling continuous monitoring of metabolic and redox processes during physical activity. Exercise elicits rapid and spatially heterogeneous shifts in redox homeostasis, driven by reactive oxygen and nitrogen species and by changes in metabolic intermediates. Traditional postexercise biochemical assays typically capture only end‐point markers and cannot resolve these short‐lived events. In contrast, bioelectrocatalytic sensing integrates biological catalysts with electrochemical transducers to track biomarkers such as lactate, glucose, hydrogen peroxide, nitric oxide, and antioxidant species in sweat, interstitial fluid, and muscle tissue with high temporal resolution. Recent wearable microfluidic platforms, microneedle devices, implantable fiber microelectrodes, and self‐powered enzymatic biofuel cells now extend measurements across biofluids and exercise intensities, yielding new insight into localized oxidative signaling, compartment‐specific metabolite kinetics, and the interplay between oxidant production and adaptive protective responses. These technologies also expose interpretive challenges, including biofluid‐specific delays, glandular contributions to sweat metabolites, oxygen dependence of oxidase‐based sensors, and the need for multianalyte integration to distinguish metabolic stress from confounders. Collectively, emerging bioelectrochemical tools are transforming the study of muscle redox dynamics and opening avenues for personalized exercise monitoring, mechanistic research, and future closed‐loop interventions in athletic and clinical settings.
Ma et al. (Wed,) studied this question.