Multi‐Centre Study by UK NEQAS Blood Coagulation: A Product Specific Calibrator Would Correct Assay Related Differences in Samples Containing Efanesoctocog Alfa for Multiple One Stage and Chromogenic FVIII Assay Methods

Key Points

• The aim is to evaluate if a product-specific calibrator can reduce differences in coagulation assay results with efanesoctocog alfa.
• Conducted a collaborative multi-centre study across various laboratories.
• Implemented multiple one-stage and chromogenic FVIII assay methods.
• Compared results with and without the product-specific calibrator.
• The product-specific calibrator significantly reduced assay-related differences.
• Corrected variance in FVIII measurements across different assay methods.
• Improved consistency in results when analyzing samples with efanesoctocog alfa.