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April 22, 2026Journal of Surgical Oncology0 citationsOpen Access

Cytoreductive Surgery in Patients With Metastatic Succinate Dehydrogenase‐Deficient Gastrointestinal Stromal Tumors

KCK ChenUniversity of California, San Diego MAMark AntkowiakUniversity of San Diego ASAshwyn K. SharmaUniversity of San Diego

Key Points

To evaluate the effectiveness of cytoreductive surgery in patients with metastatic succinate dehydrogenase-deficient gastrointestinal stromal tumors.
Analyzed disease outcomes in patients undergoing cytoreductive surgery (CRS)
Compared results to prior systemic therapies
Patients achieving complete cytoreduction (CC-0) saw longer disease control.
Cytoreductive surgery was more effective than previous systemic therapies for this patient group.

Abstract

Patients who underwent CC-0 CRS achieved prolonged disease control versus prior systemic therapies, suggesting that CRS may be a management option for highly selected SDH-deficient GIST patients.

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