Integration of Genome‐Wide Association Studies With Single‐Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes

Key Points

• This research aims to identify stroke susceptibility genes by integrating single-cell eQTL with genome-wide association studies.
• Utilized genome-wide association study data focused on stroke subtypes
• Integrated single-cell expression quantitative trait loci data to pinpoint causal genes
• Analyzed cell-type-specific gene expression patterns related to stroke
• Identified novel genes associated with stroke susceptibility linked to specific cell types
• Highlighted potential therapeutic targets for stroke prevention
• Advanced understanding of genetic factors influencing stroke pathogenesis