Background: Uvaria ovata is a medicinal plant widely used in traditional medicine, but its individual phytochemical effects on male reproduction remain unclear. Methods: Twenty-four adult male albino rats were divided into four groups (n = 6): control, alkaloid-, tannin-, and flavonoid-treated groups. Extracts (100 mg/kg) were administered orally for 28 days. Body and organ weights, sperm parameters, serum testosterone, and testicular histology were evaluated. Results: Alkaloid fractions significantly reduced sperm count, motility, and testosterone levels, with marked testicular degeneration. Tannin fractions caused moderate suppression of reproductive indices. Flavonoid fractions significantly improved sperm parameters and testosterone levels while preserving testicular architecture. Conclusion: Alkaloids and tannins exhibit anti-fertility effects, whereas flavonoids enhance reproductive function, suggesting potential therapeutic applications.
Precious Ebisintei (Thu,) studied this question.