MTHFR C677T and A1298C Gene Variants in Patients with Turner Syndrome and Their Mothers

Key Points

• To examine the association of MTHFR gene variants C677T and A1298C with Turner Syndrome risk in children and their mothers.
• Population analysis of individuals with Turner Syndrome and their mothers
• Genetic testing for C677T and A1298C MTHFR variants
• Assessment of any correlation between the variants and Turner Syndrome presence
• No association found between MTHFR C677T variant and Turner Syndrome risk.
• No association found between MTHFR A1298C variant and Turner Syndrome risk.
• Overall risk of having a child with Turner Syndrome did not link to either MTHFR variant.