What question did this study set out to answer?

Examine the relationship between CVR and gestational age in cases of congenital cystic adenomatoid malformation.

April 23, 2026Open Access

Mathematical reappraisal of the congenital cystic adenomatoid malformation volume ratio

Key Points

Examine the relationship between CVR and gestational age in cases of congenital cystic adenomatoid malformation.
Analyzed the relationship between CVR and gestational age using a quadratic equation framework.
Assessed the appropriateness of using a fixed CVR value for predicting outcomes.
Findings indicate CVR increases with gestational age due to dimensional factors.
Fixed CVR value of 1.6 cm² may not effectively predict fetal hydrops or neonatal demise.

Abstract

The CVR increases with gestational age because it results from the division of two parameters of different dimensions, with a resulting quadratic equation. Thus, the size of the CPAM necessary to produce a CVR greater than 1.6 cm2 decreases with gestational age. Therefore, the use of a fixed value of the CVR, e.g. 1.6 cm2, to predict fetal hydrops or neonatal demise, is inappropriate. A different ultrasound index that is independent of gestational age should be used in the counseling of patients with CPAM.

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