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April 23, 2026Open Access

Transcriptome Analysis and Histological Validation Identified the HO ‐1‐ u ‐1 Cell Line as a Model for Perineural Invasion in Oral Squamous Cell Carcinoma

Key Points

To identify pathways driving perineural invasion in oral squamous cell carcinoma (OSCC) and validate a cell line model.
Conducted transcriptome analysis of specific OSCC cell lines
Utilized histological validation techniques
Identified HO-1-u-1 cell line for further studies
HO-1-u-1 exhibits strong neurotropic properties
It serves as a valuable xenograft model for studying PNI in OSCC
Distinct pathways implicated in perineural invasion of different OSCC types

Abstract

Our transcriptome analysis suggested that different pathways might drive PNI in TSCC and FOMSCC, depending on their origin. We also demonstrated that HO-1-u-1 is a unique OSCC cell line with strong neurotropic properties and a valuable xenograft model for OSCC PNI.

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