A 5-month exercise training program improved exercise capacity and ejection fraction, reduced biventricular oxidative metabolism, and increased LV forward work efficiency in patients with DCM.
Cohort (n=20)
Does a five-month exercise training program improve myocardial oxidative metabolism and efficiency in patients with idiopathic dilated cardiomyopathy and mild heart failure?
A five-month exercise training program improves exercise tolerance, left ventricular function, and myocardial energetic efficiency in patients with dilated cardiomyopathy.
OBJECTIVES: The aim of this study was to determine the effect of exercise training on myocardial oxidative metabolism and efficiency in patients with idiopathic dilated cardiomyopathy (DCM) and mild heart failure (HF). BACKGROUND: Exercise training is known to improve exercise tolerance and quality of life in patients with chronic HF. However, little is known about how exercise training may influence myocardial energetics. METHODS: Twenty clinically stable patients with DCM (New York Heart Association classes I through III) were prospectively separated into a training group (five-month training program; n = 9) and a non-trained control group (n = 11). Oxidative metabolism in both the right and left ventricles (RV and LV) was measured using (11)Cacetate and positron emission tomography. Myocardial work power was measured using echocardiography. Myocardial efficiency for forward work was calculated as myocardial work power per mass/LV oxidative metabolism. RESULTS: Significant improvements were noted in exercise capacity (VO(2)) and ejection fraction in the training group, whereas no changes were observed in the non-trained group. Exercise training reduced both RV and LV oxidative metabolism and elicited a significant increase in LV forward work efficiency, although no significant changes were observed in the non-trained group. CONCLUSIONS: Exercise training improves exercise tolerance and LV function. This is accompanied by a decrease in biventricular oxidative metabolism and enhanced forward work efficiency. Therefore, exercise training elicits an energetically favorable improvement in myocardial function and exercise tolerance in patients with DCM.
Stolen et al. (Sat,) conducted a cohort in Idiopathic dilated cardiomyopathy (DCM) and mild heart failure (HF) (n=20). Exercise training vs. Non-trained control was evaluated on Myocardial oxidative metabolism and efficiency. A 5-month exercise training program improved exercise capacity and ejection fraction, reduced biventricular oxidative metabolism, and increased LV forward work efficiency in patients with DCM.