Preoperative Exposure to Sodium-Glucose Cotransporter-2 Inhibitors and Acute Kidney Injury After Cardiac Surgery: A Retrospective Single-Centre Cohort Study With Overlap Weighting Propensity Score Analysis

Key Points

• The aim is to evaluate whether preoperative SGLT2 inhibitor exposure reduces the risk of acute kidney injury following cardiac surgery.
• Retrospective cohort design
• Overlap weighting propensity score analysis
• Single-centre data evaluation
• No significant association found between SGLT2 inhibitor exposure and reduced acute kidney injury rates.
• Study was underpowered to exclude a potentially important effect.