Pooling randomized trials of antihypertensive treatment in elderly patients showed a significant 28% decrease in cardiovascular mortality and a 41% reduction in cerebrovascular mortality.
Meta-Analysis
Does antihypertensive drug treatment reduce total and cause-specific mortality in elderly hypertensive patients?
Pooling data from randomized trials demonstrates that antihypertensive therapy in the elderly significantly reduces cardiovascular and cerebrovascular mortality.
Effect estimate: 28% reduction (cardiovascular mortality)
Results on total and cause-specific mortality from various randomized intervention trials on antihypertensive drug treatment in elderly hypertensives are reviewed, compared and pooled. Mortality from all causes tended to decrease in all trials, but this decrease was not statistically significant in any of the trials separately, nor when all results were pooled. When the results of all the trials were combined, there was a significant overall decrease in cardiovascular mortality of 28%. This decrease in cardiovascular mortality was mainly related to a significant reduction in cerebrovascular mortality of 41%. Mortality from coronary heart disease also tended to decrease by 28%, but statistical significance was not reached.
Staessen et al. (Mon,) conducted a meta-analysis in Hypertension. Antihypertensive drug treatment was evaluated on Total and cause-specific mortality (28% reduction (cardiovascular mortality)). Pooling randomized trials of antihypertensive treatment in elderly patients showed a significant 28% decrease in cardiovascular mortality and a 41% reduction in cerebrovascular mortality.