What question did this study set out to answer?

This research aims to investigate the relationship between endovascular profiles and neutrophil activation in children and young adults with long COVID.

April 25, 2026Open Access

Endovascular profiles linked to neutrophil activation in children and young adults with long COVID

Key Points

This research aims to investigate the relationship between endovascular profiles and neutrophil activation in children and young adults with long COVID.
Analyzed endothelial biomarkers and microclot burden in individuals with long COVID.
Examined the role of neutrophil markers and endothelial cytokines as potential biomarkers.
Elevated endothelial biomarkers were observed in children and young adults with long COVID.
Increased microclot burden was noted in the blood of affected individuals.
Neutrophil activation was linked to ongoing endovascular injury in long COVID.

Abstract

Children and young adults with long COVID display elevated endothelial biomarkers, underscoring disease-related rather than age-related endovascular profiles following SARS-CoV-2 infection. Children and young adults with long COVID exhibit increased microclot burden in blood. Neutrophil activation may contribute to ongoing endovascular injury in long COVID. A combination of microclots, neutrophil markers, and endothelial cytokines could serve as biomarkers for Long COVID.

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Cite This Study

Steifman et al. (Wed,) studied this question.

synapsesocial.com/papers/69ec598788ba6daa22dab4d2 https://doi.org/https://doi.org/10.1038/s41390-026-05024-1

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